2015年11月16日 星期一

Generation of a synthetic lethality anti-cancer drug screen platform through investigating the role of C-Raf/DAPK complex in mitochondrial function


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The Role of HIFs Involved in the Drug Resistance of Sunitinib treatment in RCC



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The Role of Histone Deacetylase Inhibitor Mediated G2/M Cell-Cycle Arrest in Prostate Cancer Cells


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Analyze the differential effect of LBH589 in androgen dependent and independent prostate cancers


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查岱龍實驗室 成員簡介

查岱龍實驗室 成員簡介


Postdoctoral researcher

 
蔡易達 Yi-Ta Tsai
國防醫學院 醫學科學研究所 博士
E-mail: feg81230@gmail.com
Tel: 02-87923100 #19391

Consultant
高建璋 Chien-Chang Kao
三軍總醫院 泌尿外科 主治醫師
國防醫學院 醫學科學研究所 博士班就讀中

 楊明昕 Ming-Hsin Yang
三軍總醫院 泌尿外科 主治醫師
英國倫敦大學瑪莉皇后學院腫瘤幹細胞學系 博士

PhD Student
劉恩廷 En-Ting Liu
國防醫學院 生命科學研究所 博士班



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查岱龍實驗室 研究簡介

　










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查岱龍實驗室 著作發表

研究成果發表

  1. Tzeng SF, Tsai CH, Chao TK, Chou YC, Yang YC, Tsai MH, Cha TL, Hsiao PW. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer. FASEB J. 2018 Jun 15:fj201800687.
  2. Hou TY, Chen MR, Chou YC, Kan PC, Tsai YT, Cha TL. Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis. Front Immunol. 2017 Jul 10;8:790. 
  3. Lai XM, Liu SY, Tsai YT, Sun GH, Chang SY, Huang SM, Cha TL. HAF mediates the evasive resistance of anti-angiogenesis TKI through disrupting HIF-1α and HIF-2α balance in renal cell carcinoma. Oncotarget. 2017 Jul 25;8(30):49713-49724. 
  4. Tsai CH, Tzeng SF, Chao TK, Tsai CY, Yang YC, Lee MT, Hwang JJ, Chou YC, Tsai MH, Cha TL, Hsiao PW. Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells. Cancer Res. 2016 Oct 1;76(19):5756-5767.
  5. Yi-Ta Tsai, Mei-Jen Chuang , Shou-Hung Tang, Sheng-Tang Wu , Yu-Chi Chen , Guang-Huan Sun, Pei-Wen Hsiao , Shih-Ming Huang, Hwei-Jen Lee , Cheng-Ping Yu, Jar-Yi Ho, Hui-Kuan Lin, Ming-Rong Chen, Chung-Chih Lin , Sun-Yran Chang, Victor C. Lin , Dah-Shyong Yuand Tai-Lung Cha. Novel Cancer Therapeutics with Allosteric Modulationof The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Res. 2015 Jun 22.
  6. Tang SH, Huang HS, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS, Cha TL. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo. Oncotarget. 2014 Nov 15;5(21):10342-55.
  7. Tsao CW, Liu CY, Cha TL, Wu ST, Sun GH, Yu DS, Chen HI, Chang SY, Chen SC, Hsu CY. Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population. J Chin Med Assoc. 2014 Oct;77(10):513-8.
  8. Chen CL, Tang SH, Cha TL, Meng E, Tsao CW, Sun GH, Yu DS, Chang SY, Wu ST. Combined Y-shaped common channel transureteroureterostomy with Boari flap to treat bilateral long-segment ureteral strictures. BMC Res Notes. 2014 Aug 20;7:550.
  9. Tsao CW, Liu CY, Cha TL, Wu ST, Chen SC, Hsu CY. Exploration of the association between chronic periodontal disease and erectile dysfunction from a population-based view point. Andrologia. 2014 May 18.
  10. Yang MH, Tsao CW, Wu ST, Chuang FP, Meng E, Tang SH, Sun GH, Yu DS, Chang SY, Cha TL. The effect of circumcision on young adult sexual function.  Kaohsiung J Med Sci. 2014 Jun;30(6):305-9.
  11. Chen CL, Wu ST, Kao CC, Cha TL, Lee CY, Tang SH. Short-term result of renal transplantation using extracorporeal membrane oxygenation-supported brain-dead donors. Transplant Proc. 2014 May;46(4):1061-3.
  12. Chen CL, Sun GH, Cha TL. Mature cystic teratoma of the testis with involvement of the complete colonic wall. Kaohsiung J Med Sci. 2014 Apr;30(4):217-8.
  13. Huang CS, Tang SJ, Chung LY, Yu CP, Ho JY, Cha TL, Hsieh CC, Wang HH, Sun GH, Sun KH. Galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney cancer. J Am Soc Nephrol. 2014 Jul;25(7):1486-95.
  14. Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Liu SY, Huang SM, Yu DS. Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth. Mol Carcinog. 2013 Sep 20.
  15. Chuang MJ, Wu ST, Tang SH, Lai XM, Lai HC, Hsu KH, Sun KH, Sun GH, Chang SY, Yu DS, Hsiao PW, Huang SM, Cha TL. The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation. PLoS One. 2013 Sep 4;8(9):e73401.
  16. Chen CL, Tang SH, Wu ST, Meng E, Tsao CW, Sun GH, Yu DS, Chang SY, Cha TL. Calcified, minimally fat-contained angiomyolipoma clinically indistinguishable from a renal cell carcinoma. BMC Nephrol. 2013 Jul 22;14:160.
  17. Ho JY, Hsu RJ, Wu CL, Chang WL, Cha TL, Yu DS, Yu CP. Ovatodiolide Targets β -Catenin Signaling in Suppressing Tumorigenesis and Overcoming Drug Resistance in Renal Cell Carcinoma. Evid Based Complement Alternat Med. 2013;2013:161628.
  18. Chen CL, Cha TL, Wu ST, Tang SH, Tsao CW, Meng E. Renal infarction secondary to ketamine abuse. Am J Emerg Med. 2013 Jul;31(7):1153.e3-5.
  19. Yu CP, Ho JY, Huang YT, Cha TL, Sun GH, Yu DS, Chang FW, Chen SP, Hsu RJ. Estrogen inhibits renal cell carcinoma cell progression through estrogen receptor-β activation. PLoS One. 2013;8(2):e56667.
  20. Tsao CW, Lin MH, Wu ST, Meng E, Tang SH, Chen HI, Sun GH, Yu DS, Chang SY, Cha TL. Combining prostrate-specific antigen and Gleason score increases the diagnostic power of endorectal coil magnetic resonance imaging in prostate cancer pathological stage. J Chin Med Assoc. 2013 Jan;76(1):20-4.
  21. Yang MH, Sun GH, Yu DS, Chang SY, Ma CP, Cha TL. CEA-producing urothelial cell carcinoma with metastasis presenting as a rectal adenocarcinoma. Kaohsiung J Med Sci. 2012 Nov;28(11):624-7.
  22. Hsu RJ, Ho JY, Cha TL, Yu DS, Wu CL, Huang WP, Chu P, Chen YH, Chen JT, Yu CP. WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway. PLoS One. 2012;7(10):e47649.
  23. Kao CC, Cha TL, Sun GH, Yu DS, Chen HI, Chang SY, Ma CP, Wu ST. Cost-effective homemade specimen retrieval bag for use in laparoscopic surgery: experience at a single center. Asian J Surg. 2012 Oct;35(4):140-3.
  24. Kao CC, Chang YH, Wu T, Sun GH, Yu DS, Chang SY, Cha TL. Open, multi-center, phase IV study to assess the efficacy and tolerability of triptorelin in Taiwanese patients with advanced prostate cancer. J Chin Med Assoc. 2012 Jun;75(6):255-61.
  25. Ho MY, Tang SJ, Chuang MJ, Cha TL, Li JY, Sun GH, Sun KH. TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. Mol Cancer Res. 2012 Aug;10(8):1109-19.
  26. Tang SH, Kao CC, Wu ST, Meng E, Cha TL. Inlay buccal mucosal graft for reoperative posterior urethroplasty. Kaohsiung J Med Sci. 2012 Apr;28(4):220-4.
  27. Meng E, Young JS, Cha TL, Sun GH, Yu DS, Brading AF. Neuronal-derived nitric oxide modulates the activity of mouse detrusor smooth muscle. Neurourol Urodyn. 2012 Apr;31(4):572-8.
  28. Huang PW, Meng E, Cha TL, Sun GH, Yu DS, Chang SY. Walking-stick ureters' in ketamine abuse. Kidney Int. 2011 Oct;80(8):895.
  29. Huang PW, Cha TL, Chang HC, Wu ST. Air in the spinal disc with dissecting into psoas muscle after trauma. J Trauma. 2011 Jun;70(6):1577.
  30. Meng E, Chang HY, Chang SY, Sun GH, Yu DS, Cha TL. Involvement of purinergic neurotransmission in ketamine induced bladder dysfunction. J Urol. 2011 Sep;186(3):1134-41.
  31. Chuang FP, Lakin M, Wu ST, Cha TL, Sun GH, Montague DK. Experience with intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: dose considerations. Int J Impot Res. 2011 Jul-Aug;23(4):146-50.
  32. Li YF, Cha TL, Jin JS, Yu CP. Chromophobe renal cell carcinoma with osteosarcoma differentiation: case report and literature review. Urol Int. 2010;85(4):470-4.
  33. Lin TC, Lin CM, Chang HC, Kao CC, Sun GH, Cha TL. A left circum-aortic renal vein aneurysm. Am J Surg. 2010 Sep;200(3):e37-8.
  34. Lin CM, Kao CC, Lin TC, Cha TL, Wu ST. Giant presacral schwannoma mimicking malignancy in a man. Acta Chir Belg. 2010 May-Jun;110(3):387-9.
  35. Huang PW, Cha TL, Chang HC, Tang SH. Target lesions in the bladder from emphysematous cystitis. Kidney Int. 2010 Aug;78(3):325.
  36. Lin CT, Cha TL, Wu ST, Chuang FP. Acute fulminant colon cancer metastasis after renal transplantation. Rev Esp Enferm Dig. 2010 Jul;102(7):447-8.
  37. Lin CT, Cha TL, Chen YC, Lin CM, Yu DS, Wu ST. Waldenström macroglobulinaemia presenting as a perirenal mass: a case report. Acta Chir Belg. 2010 Mar-Apr;110(2):238-9.
  38. Kuo SM, Cha TL, Sun GH. Ejaculatory duct obstruction after transurethral resection of the prostate. Acta Chir Belg. 2009 Nov-Dec;109(6):818-9.
  39. Lin CM, Meng E, Sun GH, Cha TL. Danish Prostatic Symptom Score is not associated with lower urinary tract symptom severity. Acta Chir Belg. 2009 Nov-Dec;109(6):751-5.
  40. Lin CM, Tsai TH, Lin TC, Tang SH, Wu ST, Sun GH, Cha TL. Holmium: yttrium-aluminum-garnet laser endoureterotomy for benign ureteral strictures: a single-centre experience. Acta Chir Belg. 2009 Nov-Dec;109(6):746-50.
  41. Kao CC, Wu CJ, Sun GH, Yu DS, Chen HI, Chang SY, Ma CP, Cha TL. Congenital seminal vesicle cyst associated with ipsilateral renal agenesis mimicking bladder outlet obstruction: a case report and review of the literature. Kaohsiung J Med Sci. 2010 Jan;26(1):30-4.
  42. Juan TY, Roffler SR, Hou HS, Huang SM, Chen KC, Yu CP, Wu CC, Sun GH and Cha TL. Antiangiogenesis targeting tumor microenvironment synergizes glucoronide prodrug antitumor activity. Clin Cancer Res. 2009
  43. Cha TL, Chuang MJ, Wu ST, Sun GH, Chang SY, Yu DS, Huang SM, Huan SK, Cheng TC, Chen TT, Fan PL, Hsiao PW. Dual degradation of aurora A and B kinases by the histone deacetylase mehtylating histone H1-K26, H3-K9 and H3-K27 inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cell. Clin Cancer Res. 2009; 15(3):840-50
  44. Chuang MJ, Sun KH, Tang SJ, Deng MW, Wu YH, Sung JS, Cha TL, Sun GH. Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells. Cancer Sci 2008;99(5):905-913
  45. Lin FM, Tsai CH, Yang YC, Tu WC, Chen LR, Liang YS, Wang SY, Shyur LF, Chien SC, Cha TL, Hsiao PW. A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis. Cancer Res. 2008;68(16):6634-6642
  46. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-meidated phosphorylation of EZH2 suppresses methylation lysine 27 in histone H3. Science 005;310(5746):306-10
  47. Rau KM, Kang HY, Cha TL, Miller SA, Hung MC. The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers. Endocr. Relat. Cancer 2005;12(3):511-532 Review
  48. Cha TL, Qiu L, Chen CT, Wen Y, Hung MC. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005;65(5):2287-2295


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